The length of time do rapid diagnostic tests stay g d after anti-malarial therapy?

The length of time do rapid diagnostic tests stay g d after anti-malarial therapy?

Abstract

Background

Fast diagnostic tests (RDTs) are becoming increasingly a paradigm for both clinical diagnosis of malaria infections as well as for calculating community parasite prevalence in household malaria indicator surveys in malaria-endemic nations. The antigens detected by RDTs are known to persist into the bl dstream after treatment with anti-malarials, but reports on the period of perseverance ( plus the impact it has on RDT positivity) of these antigens post-treatment are adjustable.

Techniques

In this review, posted studies on the determination of positivity of RDTs post-treatment are collated, and a bespoke bayesian survival model is fit to calculate the number of times RDTs remain g d after treatment.

Outcomes

50 % of RDTs that detect the antigen histidine-rich protein II (HRP2) remain positive 15 (5–32) days post-treatment, 13 times much longer than RDTs that detect the antigen Plasmodium lactate dehydrogenase, and that 5% of HRP2 RDTs remain g d 36 (21–61) times after therapy.Continue reading